Previous studies showed that tRFs (5′‐tRF‐GlyGCC, tRF‐Phe‐GAA‐031, and tRF‐VAL‐TCA‐002) could serve as novel biomarkers for CRC diagnosis, and 5′‐tRF‐GlyGCC showed better diagnostic performance with CEA and CA199.3, 4. Here, CEACAM5 is linked to colorectal carcinoma.