When comparing patients who died with those who were discharged alive from the hospital, the first group was older and had a higher prevalence of underlying comorbidities such as hypertension, coronary artery disease, heart failure, chronic obstructive pulmonary disease, and cancer, moreover lower platelet levels, higher urea, and C-reactive protein levels, at ICU admission (Supplementary Table S1). This evidence concerns the gene CRP and chronic obstructive pulmonary disease.