We can also speculate about the effect of HLA-DRB1*03:01 homozygosity on better prognosis as four of five homozygotes among our Czech sarcoidosis patients had a remitting disease, a similar relationship was previously observed in HLA-DRB1*03:01 homozygous patients with remission of multiple sclerosis (29). This evidence concerns the gene HLA-DRB1 and sarcoidosis.