In line with their role in sarcoidosis immunopathogenesis (1, 8, 18), HLA class II loci emerged as the central location of the disease-associated variants: HLA-DQB1*06:02, here defined as a risk variant; was previously reported to be associated mainly with a worse prognosis in sarcoidosis in Swedish and Dutch patients (14, 19) and linked with variants HLA-DRB1*15:01 and HLA-B*07 (15). This evidence concerns the gene HLA-DRB1 and sarcoidosis.