On the other hand, adeno-associated virus vector serotype 9 carrying LECT2 short hairpin RNA (AAV9-LECT2-shRNA) can target mouse LECT2 to inhibit LECT2/Tie1 signaling, thereby inducing portal angiogenesis, suppressing hepatic sinusoidal capillarization, and alleviating liver fibrosis (90). The gene discussed is TIE1; the disease is Hepatic fibrosis.