Interestingly, two out of eight patients diagnosed with precancerous EIN (endometrial intraepithelial neoplasia) carried a PV in BRCA1. Unfortunately, the histologic subtypes of endometrial carcinomas other than endometrioid were rarely represented, thus the frequencies of PVs in these subgroups cannot be calculated and compared. The gene discussed is BRCA1; the disease is endometrial carcinoma.