While we have found eight PV carriers in HBOC genes and four carriers in LS genes (including a patient with co-occurrence of BRCA1 and MLH1 PV and diagnosed with EC, OC, and BC) in the group of 69 patients with EC and OC (11.6%), we have identified eight carriers of LS genes mutation and only one additional carrier of the CHEK2 gene mutation (a patient with EC, CRC, and melanoma) in the group of 34 patients with EC and CRC (26.5%). This evidence concerns the gene CHEK2 and colorectal carcinoma.