People with HIV who had CD4+ counts < 350 cells/mL or viral load ≥ 1000 copies/mL had increased risk of death from tuberculosis compared to virally suppressed patients (adjusted relative risk: 2.10 [95% CI: 1.44–3.04, P < 0.009] and 1.56 [95% CI: 1.22–2.00, P < 0.001]). This evidence concerns the gene CD4 and tuberculosis.