Intriguingly, tumor tissues of bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), kidney chromophobe (KICH), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), and prostate adenocarcinoma (PRAD) express CX3CL1 at significantly lower levels than normal tissues. The gene discussed is CX3CL1; the disease is squamous cell lung carcinoma.