Previous research has demonstrated that CX3CL1 plays a crucial function in numerous types of cancers, including ovarian carcinoma (Singh et al., 2019), B-cells lymphoma (Corcione et al., 2010), neuroblastoma (Nevo et al., 2009), breast cancer (Onitilo et al., 2009), gastric cancer (Lv et al., 2014), pancreatic cancer (Xu et al., 2012; Ran et al., 2020), prostate cancer (Tang et al., 2016), colorectal cancer (Zheng et al., 2013), lung cancer (Schmall et al., 2015), and hepatocellular cancer (Huang and Geng, 2010). This evidence concerns the gene CX3CL1 and hepatocellular carcinoma.