Similarly, it was also reported that the activation of the amyotrophic lateral sclerosis and glycosaminoglycan degradation signal pathways in the GSEA results of AMPD3 could be due to the increased expression of AMPD3 (Miller et al., 2021), indicating that the crutial significance of the over-expression of AMPD3 in T2D progression. The gene discussed is AMPD3; the disease is type 2 diabetes mellitus.