IER3 and amyotrophic lateral sclerosis: Moreover, the results of GSEA analysis between these genes in the high- and low-expression groups of hypoxia-immune-related hub genes showed that the KEGG pathways of genes in high-expression groups of AMPD3 and IER3 were mainly enriched in “glycosaminoglycan degradation,” “amyotrophic lateral sclerosis,” “nicotinate and nicotinamide metabolism” and “vasopressin-regulated water reabsorption,” while the genes in low-expression groups of AMPD3 and IER3 were mainly in “RNA degradation” and “nucleotide excision repair” (Figures 7B, C).