Studies reveal that NALCN is expressed in some cancers, such as glioblastoma, non-small cell lung cancer (NSCLC), pancreatic cancer, small cell lung cancer (SCLC) and tumor-derived endothelial cells (Lee et al., 2013; Cochet-Bissuel et al., 2014; Djamgoz, 2020). Here, NALCN is linked to familial pancreatic carcinoma.