For example, overexpression of ceramide synthase 2 (CERS2), a catalyst for the synthesis of very-long-chain fatty acids (VLCFAs) in hepatocytes, enhances insulin signaling despite elevating the total level of ceramide (66), whereas the depletion of CERS2 in WAT and liver results in weight gain and deterioration of insulin resistance (67). Here, INS is linked to Insulin resistance.