Generally, the alteration of autophagy (either site-dependently enhanced or suppressed) in the context of obesity is complicated since they depend on various conditions (93) (Figure 4), where the hyperactivation of mTOR under overnutrition leads to the suppression of autophagy owing to the imbalance between calorie intake and energy expenditure (94). This evidence concerns the gene MTOR and obesity due to melanocortin 4 receptor deficiency.