To further explore the impact of additional risk factors on the correlation of the TyG index with the risk of ESRD, subgroup analyses were conducted in accordance with the following stratification variables: age (≥ 60 or < 60 years), age of onset of DM (≥ 58 or < 58 years), DM duration (≥ 12 or < 12 months), sex (male or female), anemia (yes or no), MAP (≥ 100 or < 100 mmHg), hyperlipidemia (yes or no), insulin treatment (yes or no), BMI (≥ 24 or < 24 kg/m2), HF (yes or no), stroke (yes or no), and RAAS inhibitor treatment (yes or no). This evidence concerns the gene INS and diabetes mellitus.