AGT and familial dilated cardiomyopathy: In the pathogenesis of DCM, there is an imbalance in the release of vasoconstrictors [for example, prostanoids, endothelin, and angiotensin-II(Ang-II)] and diastolic agents [for example, nitric oxide (NO), prostacyclin (PGI2), bradykinin, and endothelium-derived hyperpolarizing factor (EDHF)] (49).