first used the index of GDF-15/adiponectin ratio (G/A ratio), whose increment was independently associated with the risk of T2DM for all study populations, compared to GDF-15 or adiponectin alone, suggesting the combination of these two adipokines might have an “enhancing effect” on predicting the risk of T2DM (17). Here, GDF15 is linked to type 2 diabetes mellitus.