Agrin is known for its ability to aggregate acetylcholine receptors (AChR) at the neuromuscular junction, can act as an ECM sensor, and has functions to stabilize FAs and promote HCC (Chakraborty et al., 2015), and acts as an ECM signal that can be recognized by the integrin/Lrp4/MuSK receptors, which is necessary and sufficient to maintain YAP activity in response to mechanical changes (Chakraborty et al., 2017; Xiong and Mei, 2017). Here, AGRN is linked to hepatocellular carcinoma.