ACTA1 and hydrops fetalis: In the experimental hepatic fibrosis model induced by dimethylnitrosamine (DMN), the incidence of HF in rats orally administered Y27632 was significantly reduced, the proliferation and diffusion of HSCs were continuously reduced, the expression of hydroxyproline and α-SMA were downregulated, fiber assembly was significantly reduced, and the transcription level of type I collagen mRNA was significantly inhibited (Tada et al., 2001).