The sequence of development of hepatitis, HF, and cirrhosis (advanced HF), liver cancer is considered to be the classic trilogy of liver cancer, and although the role of Agrin in activating YAP/TAZ or mediating cell/matrix stiffness is less studied, understanding the agrin-YAP mechanotransduction pathway may help develop therapeutic strategies for diseases including HF, liver cancer. The gene discussed is AGRN; the disease is hepatitis A virus infection.