In addition, eIF3a was involved in cell cycle arrest, cell apoptosis, cell proliferation (Yin et al., 2018), embryo development (Liu et al., 2007), virus infection (Buratti et al., 1998; Rodriguez Pulido et al., 2007; Wang et al., 2012; Subramani et al., 2018), promotion of tumor initiation and development, and chemotherapy and radiation therapy of cancers (Yin et al., 2011a; Yin et al., 2018). This evidence concerns the gene EIF3A and viral infectious disease.