Among the current tau positron emission tomography (PET) tracers, [11C]PBB3 and [18F]PM-PBB3 can detect non-AD tauopathy and rTg4510 tau pathology (Maruyama et al., 2013; Ishikawa et al., 2018; Tagai et al., 2021; Kimura et al., 2022; Figures 1B–F). This evidence concerns the gene MAPT and Alzheimer disease.