However, the expression of Cleaved-caspase 3 and Bax, which was increased in the CHF group compared to that in the SO group, and decreased in the PIT group compared to that in the CHF group, was decreased in the M2R+ group and increased in the M2R− group compared to that in the PIT group (Figure 7D). The gene discussed is CASP3; the disease is congestive heart failure.