The knockdown of the epilepsy candidate gene Klp3A in flies (tub-Gal4 > UAS-Klp3A-RNAi) resulted in a significantly higher occurrence of late-phase seizures (22.27 ± 8.49%, n = 5) compared to the UAS-Klp3A-RNAi flies (0.00 ± 0.00%, n = 5, p = 0.0002, one-way ANOVA, Tukey’s multiple comparisons test). This evidence concerns the gene TUB and epilepsy.