Drosophila is advantageous in the study of epilepsy due to its ability to map genetic interactions, which is facilitated by powerful resources and techniques such as genome-wide RNAi transgenic stocks (Dietzl et al., 2007; Ni et al., 2011), collections of mapped transposon insertion alleles, Gal4/UAS system, and the recently developed CRISPR/Cas9 system. The gene discussed is LGALS4; the disease is epilepsy.