SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Like SCN1A LOF variants in Dravet syndrome, recent studies described the expression of NaV1.2 channels in inhibitory neurons, indicating the mechanism of epilepsy due to SCN2A loss-of-function variants could also be the imbalance of excitatory/inhibitory neurons.