Consistent with KDM5B protein expression in the PCa tumor specimens reported here, KDM5B mRNA expression was higher in both androgen dependent (LNCaP) and androgen-independent (LNCaP: C4-2, 22Rv1, PC3) cell lines as compared to the non-malignant PNT1A prostate cell line. The gene discussed is KDM5B; the disease is posterior cortical atrophy.