SKP2 was previously shown to be elevated in PCa progression which in-turn regulated TRAF E3 ubiquitin ligase ubiquitylation of KDM5B which led to loss of demethylase function, nuclear re-localisation of KDM5B and increase in H3K4me3 (Lu et al., 2015). This evidence concerns the gene SKP2 and posterior cortical atrophy.