For this reason, we have completed a clinical and mechanistic analysis of KDM5B in PCa cell lines, prostate adenocarcinoma and neuroendocrine tumor patient specimens and examined the effect of individual and cooperative inhibition of KDM1A (Willmann et al., 2012) and KDM5B (Vinogradova et al., 2016) on androgen regulated gene expression. This evidence concerns the gene KDM5B and neuroendocrine neoplasm.