Consistent with a pro-oncogenic function for KDM5B, prostate-specific depletion of KDM5B and PTEN in the mouse prostate epithelium and PCa cell lines supports a role for KDM5B in activating the PI3K/AKT pathway in prostate carcinogenesis (Li et al., 2020). The gene discussed is PTEN; the disease is posterior cortical atrophy.