Thus, inhibition of the aspartate efflux-related protein, mitochondrial transporter uncoupling protein 2 (UCP2), resulted in reduced glutamine hydrolysis and NADPH/NADP+ and glutathione/glutathione disulfide ratios as well as increased levels of reactive oxygen species in KRAS-mutated pancreatic cancer cell lines. The gene discussed is KRAS; the disease is familial pancreatic carcinoma.