AIFM2 and familial pancreatic carcinoma: However, an answer to this query was soon available, and recent studies have shown that KRASG12D can activate the MAPK signaling pathway, which in turn further activates NRF2, which in turn upregulates the expression of FSP1 (ferroptosis suppressor protein 1) and removes excess ROS, allowing pancreatic cancer cells to proliferate stably under safe conditions (Deramaudt and Rustgi, 2005).