Mechanistically, a study revealed that KRASG12D induced HnRNPA1 hyperactivation, interacted with TSG101, and enhanced hnRNPA1 packaging and delivery via EVs, which were internalized by human endothelial lymphocytes in the tumor microenvironment and promoted lymph node metastasis (Luo et al., 2022). The gene discussed is HNRNPA1; the disease is neoplasm.