STAT3 and pancreatic neoplasm: A high-fat, high-calorie diet (HFCD) increased pancreatic cancer incidence in P48+/Cre, LSL-KRASG12D (KC) mice, resulting in their exhibition of more extensive inflammation and fibrosis (Chang et al., 2017).A study showed that KRASG12D could upregulate FGL1 through the phosphorylation of STAT3, altering lipid metabolism and promoting the proliferation of PDAC cells (Chiu et al., 2021).