Glutamine-derived aspartate is translocated to the cytoplasm, subsequently, oxaloacetate is converted to malate and pyruvate, increasing the NADPH/NADP (+) ratio and thus maintaining the redox state of pancreatic cancer cells, which makes KRAS-mutated pancreatic cancer cells dependent on this pathway (Son et al., 2013). The gene discussed is KRAS; the disease is familial pancreatic carcinoma.