LDHA and familial pancreatic carcinoma: It was found that overexpression of FBW7 in pancreatic cancer cells activates the c-Myc signaling pathway to target thioredoxin-binding protein (TXNIP), a negative regulator of glucose metabolism, which in turn inhibits glycolysis-related genes, including GLUT1, GLUT4, HK2, LDHA and LDHB.