Furthermore, in lung adenocarcinoma, circdcun1d4 can bind the HuR protein, which elevates HuR activity, and acts as a scaffold to interact with thioredoxin interacting protein (TXNIP) mRNA, increasing the stability of TXNIP mRNA, which then plays a protective role in lung adenocarcinoma (Liang et al., 2021). Here, TXNIP is linked to lung adenocarcinoma.