reported that circnsun2 binds to insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) to target high mobility group AT-hook 2 (HMGA2), forming the circnsun2/IGF2BP2/HMGA2 RNA protein ternary complex, which is involved in promoting colorectal carcinoma formation (Chen et al., 2019b). Here, HMGA2 is linked to colorectal carcinoma.