In glioma, circCDK14 was found to reduce the likelihood of ferroptosis occurring in glioma cells by regulating the expression levels of platelet derived growth factor receptor alpha (PDGFRA), which is closely associated with poor prognosis in glioma patients and promotes the malignant progression of gliomas (Chen et al., 2022). The gene discussed is PDGFRA; the disease is central nervous system cancer.