SERPINA1 and Hepatic fibrosis: The systemic application of autophagy inducer rapamycin, carbamazepine, or norursodeoxycholic acid in the Z-AAT transgenic mice has been described to ameliorate liver fibrosis and inflammation via enhancing autophagic flux and reducing Z-AAT aggregates (Hidvegi et al., 2010; Kaushal et al., 2010; Tang et al., 2016; Wang et al., 2019).