De novo and inherited mutations in CNOT3 are also associated with the intellectual developmental disorder with speech delay, autism, and dysmorphic facies (IDDSADF) suggesting that the recruitment of Ccr4-Not by CNOT3 to transcripts with minor codons and low translational efficiency is essential for development (Meyer et al., 2020). This evidence concerns the gene CNOT3 and Delayed speech and language development.