NLRP3 and colitis: Promotion of autophagy in macrophages inhibits CD susceptibility gene protein tyrosine phosphatase non-receptor type 2 (PTPN2)-mediated initiation and activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, which triggers the maturation of pro-inflammatory cytokines such as IL-1β and IL-18 thereby inhibiting colitis [112,113].