YAP1 and colorectal carcinoma: Mechanistically, METTL3 drives m6A modification on CRB3 mRNA in CRC cells; the m6A-YTHDF2 axis represses CRB3 protein translation efficiency and subsequently restrains the activity of Hippo pathways by reducing the level of MST1, LATS1, MOB1, and YAP phosphorylation (29).