Mechanistically, METTL3 drives m6A modification on CRB3 mRNA in CRC cells; the m6A-YTHDF2 axis represses CRB3 protein translation efficiency and subsequently restrains the activity of Hippo pathways by reducing the level of MST1, LATS1, MOB1, and YAP phosphorylation (29). The gene discussed is METTL3; the disease is colorectal carcinoma.