m6A-binding proteins contain the YT521-B homology (YTH) domain family, insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs), and heterogeneous nuclear ribonucleoproteins (HNRNPs) (71–73); Accumulating evidence suggests that m6A “readers” are greatly implicated in many human cancers, such as CRC (Table 3). Here, YTHDC1 is linked to colorectal carcinoma.