M2 macrophage abundance was negatively correlated with BACE1-AS levels in tenosynovial giant cell tumors, LIHC, lung squamous cell carcinoma, colon adenocarcinoma, prostate adenocarcinoma, and KIRC, and was positively correlated with BACE1-AS levels in thyroid carcinoma, cervical squamous cell carcinoma and endocervical adenocarcinoma, and acute myeloid leukemia. The gene discussed is BACE1; the disease is acute myeloid leukemia.