IGF1R and non-small cell lung carcinoma: A role in EMT promotion linked to acquired osimertinib resistance in NSCLC was also attributed to Let-7c (85), whereas miR-7 was demonstrated to enhance TKI-induced cytotoxicity by gefitinib through the suppression of both IGF1R (Insulin like growth factor1 receptor) and EGFR signaling pathways (86).