✓ miR-200a is downregulated in NSCLC cells, where it directly targets the 3′-UTR of both EGFR and MET mRNA.✓ Its overexpression significantly downregulates both EGFR and MET signaling pathways and severely inhibits cell migration, invasion in gefitinib resistant lung cells. Here, EGFR is linked to non-small cell lung carcinoma.