Finally, it was observed that patients without methylation in SFRP1 have a longer PFS compared with patients with its methylation (9.7 months vs 2.0 months, p = 0.05), thus suggesting the intriguing hypothesis that activation of Wnt signaling by antagonist methylation could confer staminal properties linked to the EGFR TKIs resistance in lung cancer patients (48). The gene discussed is EGFR; the disease is lung carcinoma.