SPP1 and non-small cell lung carcinoma: ✓ CD44 and SSP1 methylation are prognostic factors in LUAD patients.✓ SPP1 methylation modulates its expression and is related to 1st and 2nd EGFR-TKI resistance of NSCLC.✓ CD44-SSP1 axis is implicated in the trasformation of ADC in SCLC under EGFR-TKI selettive pressure.