In hepatocellular carcinoma, the degradation of KEAP1 mediated by P62 assists the activation of NAD(P)H quinone dehydrogenase 1 (NQO1), heme oxygenase 1 (HO1), and ferritin heavy chain 1 (FTH1) down-stream of NRF2. Here, HMOX1 is linked to hepatocellular carcinoma.