AKT1 and Immunodeficiency: Based on the allele frequency of the SNPs occurred in the patients, we found the SNPs could be divided to two distinct subgroups/clusters: cluster1 covered the majority of the “rare” variants which mainly associated with tumorigenesis involving the pathway of DNA repair, steroid hormone synthesis and immune deficiency whereas cluster2 covered most of the “common” variants which mainly associated with cancer progression or therapy response involving the pathway of PI3K-AKT signaling, MAPK signaling pathway, estrogen signaling pathway and drug metabolism pathway.