Moreover, baicalin administration, reversed mRNA expression level of TRPV1 (Sui et al., 2010) and suppressed TRPV1 upregulation and phosphorylation of extracellular signal-regulated kinases (MAPK/ERK pathway) (Wang et al., 2020) in DRG neurons after peripheral nerve injury might account for the anti-nociceptive mechanism of baicalin. This evidence concerns the gene TRPV1 and peripheral nerve injury.