Each group was tested in one session: For the POF tested after at least 6 months of the diagnosis (the presence of amenorrhea and a serum FSH level greater than 40 mIU/mL on two occasions at least 1 month apart). For the menopausal women (amenorrhea for at least 1 year). For the control group (normal regular menstrual cycle), no mention of the cycle phase or day of the testing. This evidence concerns the gene BRD2 and amenorrhea.