ICAM1 and colitis: The expression of an NF-κB p65-related gene, intercellular adhesion molecule-1 (ICAM-1) 6, 7, which is expressed by epithelial cells and mediates the initial attachment and rolling of neutrophils to the epithelium 8, was also increased in DSS-induced colitis WT mice but not in DSS-treated PAI-1 KO mice (Figure 4G and H).