We also screened for metabolism-related genes that affect the prognosis of patients with NPC in tumor cell-enriched regions (COMT, DUT, GMPS, MDH1, MDH2, NME1, PAICS, PLCB2, POLR2I, PTGS2, UCK2, ADCY3, ADCY9, CYP2J2, DNMT1, EPHX1, MBOAT7, POLD1 and UAP1). This evidence concerns the gene PAICS and nasopharyngeal carcinoma.