Conversely, the genes BZW2, DLL4, GTPBP4, LSM4, MBD3, PAICS, PALM2AKAP2, PAQR4, RUVBL1 and TGS1 represent risk factors; the higher the expression of these genes, the higher the risk of death in patients with NPC (Fig. 3B). The gene discussed is PAQR4; the disease is nasopharyngeal carcinoma.