In PanCK-expressing regions, the higher the expression of COMT (P <0.001), GMPS (P <0.001), MDH1 (P =0.001), MDH2 (P <0.001), NME1 (P <0.001), PAICS (P <0.001), POLR2I (P <0.001), and UCK2 (P =0.004), the worse was the prognosis of NPC. This evidence concerns the gene MDH2 and nasopharyngeal carcinoma.