We also screened for metabolism-related genes that affect the prognosis of patients with NPC in tumor cell-enriched regions (COMT, DUT, GMPS, MDH1, MDH2, NME1, PAICS, PLCB2, POLR2I, PTGS2, UCK2, ADCY3, ADCY9, CYP2J2, DNMT1, EPHX1, MBOAT7, POLD1 and UAP1). The gene discussed is POLD1; the disease is nasopharyngeal carcinoma.