As shown in Supplementary Figure s6A, metabolic pathways showed that in PanCK-expressing regions, metabolic genes were mainly enriched in primary immunodeficiency, Fcγ-mediated phagocytosis, regulation of actin cytoskeleton, pathways in cancer, the T cell receptor signaling pathway, P53 signaling, the one-carbon pool by folate pathway, DNA replication, purine metabolism, pyrimidine metabolism, glyoxylate and dicarboxylate metabolism, and cysteine and methionine metabolism (P <0.05). This evidence concerns the gene TP53 and inborn error of immunity.