Univariate Cox regression analysis of 171 genes in PanCK-expressing regions and 13 prognosis-related metabolic genes revealed that the expression of ADCY3 (P = 0.027), ADCY9 (P =0.028), CYP2J2 (P = 0.038), DNMT1 (P = 0.024), EPHX1 (P =0.022), MBOAT7 (P =0.018), POLD1 (P = 0.016) and UAP1 (P = 0.041) correlated positively with survival risk in patients with NPC (Fig. S6C). The gene discussed is POLD1; the disease is nasopharyngeal carcinoma.