To figure out the underlying mechanism of the downregulation of ACADL in HCC, we investigated the upstream regulator of ACADL by using hTFtarget and JASPAR2022 (Table S6, Figure S2G, H) and obtained 4 candidate TFs including FOXA2, HNF4A, TEAD4, YY1. This evidence concerns the gene HNF4A and hepatocellular carcinoma.