CPT1C and neoplasm: In addition, CPT1C knockdown blocked the pathway by which long chain fatty acid (LCFA) are transported into mitochondria and metabolized into acetyl-CoA as revealed by the decreased abundance of labeled citrate that arose from [U-13C16] palmitate, which was consistent with previous reports that CPT1C can enhance the transport of fatty acids into mitochondria and increase FAO activity in varied tumor cells 15, 21, 31-33.