To evaluate the relevance of β2-AR/CREB1 signaling with glycolysis, we analyzed the relationship between CREB1 and glycolytic genes expression through the accessible TCGA data sets of COAD and READ, and we discovered that CREB1 is positive correlated with GLUT1 (SLC2A1), HK2, PFKP (Figure S4A-S4C). This evidence concerns the gene HK2 and reading.