Multiple factors associated to subtotal cholecystectomy have been identified such as male sex (OR = 2.59) (7), older age (OR = 1.23) (7), ASA score of ≥3 (OR = 3.84) (15), white blood cells (WBC) (OR = 2.02) (7), albumin level (OR = 0.31) (16), preoperative diagnosis of acute on chronic cholecystitis (OR = 5.47) (7), acute cholecystitis (OR = 2.69) (16), higher Tokyo grade for severity of acute cholecystitis (OR = 2.37) (17), history of liver disease (OR = 8.40) (16), time from onset to surgery (OR = 5.31) (15), previous biliary tract drainage (cholecystostomy) (OR = 2.66) (16, 18). The gene discussed is ALB; the disease is liver disorder.