Correlation analysis showed that the relative abundance of Lactobacillus, Lactococcus, Streptococcus, and Lactobacillus vaginalis was strongly associated with hyperlipidemia; also, these genera and the expression of CYP7A1 and CYP8B1 were positively correlated, while Bacillus was negatively correlated with CYP7B1. This evidence concerns the gene CYP7B1 and hyperlipidemia.