HIF1A and hepatocellular carcinoma: Luteolin can regulate the mRNA expression of pro-proliferative genes, pro-apoptotic genes, and angiogenic molecules Uba2, VEGF, Fra-1, HIF-1α, and Rac1 in hepatocellular carcinoma HepG2 cells, thereby inhibiting the proliferative activity and angiogenesis of hepatocellular carcinoma cells 75.