MUC16 and bone metastasis: Likewise, positive CA-125 (HR=1.65, 95%CI=1.03-2.66, P=0.04), bone metastasis (HR=1.22, 95%CI=0.95-1.56, P<0.01), brain metastasis (HR=1.91, 95%CI=1.27-2.88, P=0.12) and liver metastasis (HR=1.25, 95%CI=1.09-1.42, P<0.01) were all Significant independent risk factors for the prognosis of OC.