In PC, hypoxic derived exosomal miR-30b-5p promoted angiogenesis by inhibiting gap junction protein alpha 1 (GJA1) 15, while miR-301a mediated M2 macrophage polarization to promote metastasis via PTEN/phosphoinositide 3-kinase-γ (PTEN/PI3Kγ) 16. This evidence concerns the gene GJA1 and pachyonychia congenita.