Early experimentation examining the role of PPARδ activation in cancer growth were controversial, with one study showing that a PPARδ agonist (GW501516) enhances tumor growth in Apc(min) mice 20, while another study in the same journal and in the same year showed enhanced tumor growth in Apc(min) mice crossed with PPARβ/δ knockout mice 21. Here, PPARD is linked to neoplasm.