In addition, comprehensive analysis of PD-L1 and CD8+ TILs in 255 Chinese NSCLC samples showed that the proportion of PD-L1+ and CD8+ TILs double positive in TME was decreased, while the proportion of PD-L1- and CD8- TILs double negative was increased in EGFR mutation group compared with EGFR wild-type group patients (P < 0.01) 19. This evidence concerns the gene EGFR and non-small cell lung carcinoma.