Through the R2 biologist web analysis with the established data set of “Mixed Osteosarcoma (Mesenchymal) -Kuijjer-127-vst-ilmnhwg6v2”, whose data source is GSE42352, we found that high expression of MYC was positively correlated with poor prognosis and enhanced metastasis in OS patients (Fig. 1A, 1B; Supplementary Table S1). This evidence concerns the gene MYC and osteosarcoma.