For example, Exon-intron circular RNAs named circ-EIF3J is able to promote its host gene EIF3J transcription by interacting with Pol II transcription complex and U1 snRNP 33; Ectopic expression of circ-Foxo3 increased Foxo3 protein levels, and promoted stress-induced apoptosis and suppressed tumor growth 34. This evidence concerns the gene FOXO3 and neoplasm.