In the present study, independent prognostic factors for rectal cancer patients were identified as age, pT stage, lymph node metastasis, elevated CEA level, tumor size, poorly differentiated/undifferentiated adenocarcinoma, PNI, CRM involvement, and inadequate lymph nodes yield, which have been reported in previous studies (14–20). Here, CEACAM5 is linked to metastatic malignant neoplasm in the lymph nodes.