CEACAM5 and neoplasm: After adjusting for potential covariates, age (p < 0.001), advanced pT stage (pT3 vs. pT1-T2 stage, p = 0.003; pT4 vs. pT1-T2 stage, p < 0.001), lymph node metastasis (pN1 vs. pN0 stage, p < 0.001; pN2 vs. pN0 stage, p < 0.001), elevated CEA level (p < 0.001), tumor size ≥5 cm (p = 0.007), PD or UD (p < 0.001), PNI (p < 0.001), CRM involvement (p < 0.001) and at least 12 lymph nodes yield (p = 0.001) were identified as independent prognostic factors (Table 3).