In some studies, the presence of tumor infiltrating lymphocytes such as CD8+ (cluster of differentiation 8) T cells, as well as interferons and chemokines has been found to result in improved response to immunotherapies (4); however the prognostic value of programmed cell death ligand-1 (PD-L1) in urothelial cancer remains controversial (5). The gene discussed is CD274; the disease is neoplasm.