The results showed that TP53, PIK3CA, EGFR, APC, ERBB3, KRAS, ROS1, FBXW7, MAP2K1, AKT3 appeared at high frequency in HACC, and the detection rate of these genes was consistent with that of the control group and the gene mutation profiles from 534 patients with COAD were obtained from The Cancer Genome Atlas (TCGA, PanCancer Atlas) database (Cancer Genome Atlas, 2012). Here, PIK3CA is linked to colon adenocarcinoma.