Cytoplasmic inclusions consisting of transactive response DNA-binding protein 43 (TDP-43) are a key hallmark of TDP-43 proteinopathies like amyotrophic lateral sclerosis (ALS).Caenorhabditis elegansis considered a useful model for studying the molecular mechanisms underlying TDP-43 toxicityin vivo. Here, TARDBP is linked to proteostasis deficiencies.