Inclusions consisting of transactive response DNA-binding protein 43 (TDP-43) are a characteristic and toxic feature of numerous neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS)(Arai et al., 2006; Neumann et al., 2006; Neumann et al., 2009). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.